Tag: 贵族宝贝

Sergio Rico hires new agent plans to depart Sevilla

first_imgSevilla goalkeeper Sergio Rico seeks a summer switch as he hires the brother of Sergio Ramos to be his new agent and source opportunities for him.Rene Ramos, the brother of Real Madrid caption Sergio Ramos is now the representative acting on behalf of Rico, states ABC de Sevilla via Football Espana.The Spanish goalkeeper who has been constantly linked with Arsenal, Milan and Napoli in the past, the 24-year-old endured a tough season with Los Rojiblancos and lost his regular starting spot to David Soria in the latter stages of the campaign. Watford are the leading candidates for the Sevilla youth product.Gerard Pique, Neymar, BarcelonaLa Liga Betting: Match-day 4 Stuart Heath – September 14, 2019 Despite it being very early into La Liga season, both Barcelona and Real Madrid have had unprecedented starts to their campaigns. With this in…Rico and Sevilla teammate Aleix Vidal were the two players called up to the Spanish national team for the first time, ahead of a friendly with Costa Rica and a UEFA Euro 2016 qualifying match against Belarus, but Rico did not play in either fixture.He was also the third-choice goalkeeper for the final tournament behind Iker Casillas and David de Gea and made his debut on 1 June, replacing the former for the final 14 minutes of a 6–1 friendly win over South Korea in Salzburg.last_img read more

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Gimenez signs a new fiveyear with Atletico Madrid

first_imgReal Madrid’s hopes of signing Jose Gimenez have ended after the defender signed a new five-year deal with Atletico Madrid that will run until 2023The European Champions were eyeing a move for the 23-year-old this summer as a potential long-term replacement for their ageing captain Sergio Ramos, who is 32.Gimenez had struggled for regular minutes under Diego Simeone last season and a move away from the Wanda Metropolitano seemed like a possibility.But he has now committed his long-term future to Atletico.“I’m so happy, I really appreciate the club’s confidence in me,” Gimenez told the club website.Sergio Ramos, Real MadridZidane reveals Sergio Ramos injury concern for Real Madrid Andrew Smyth – September 14, 2019 Zinedine Zidane has put Sergio Ramos’ availability for Real Madrid’s trip to Sevilla next weekend in doubt after withdrawing him against Levante.“Since I arrived at the club we have grown so much, we have won important titles, we have consolidated between the great times in Europe, we have a brand new stadium and it is an honour that they bet on me and to be able to keep contributing to the growth of this great project.“Miguel Angel Gil has shown me the confidence that the club puts on me in a conversation in a Montevideo. Gestures like these can’t be forgotten and this made it easy to take this decision.“We have a fantastic group that is the key to all of our sports success and since I arrived here I feel like home, that’s why I want to give my best to thank the confidence shown.“Also, I want to thank the fans for their support, it is very important for me. It’s something that my family and I wanted.”Gimenez’s release has now been increased to €120m as part of his new deal.last_img read more

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Mertens We should have done more

first_imgNapoli forward Dries Mertens is disappointed with the 1-1 draw against Roma as he believes they deserved more in the tie.Stephan El Shaarawy put Roma in the driving seat,only for Napoli who dominated the entire game to equalise late in the game thanks to Mertens.“It’s a pity, as today we could’ve picked up three important points and it’s just one,” the visibly disheartened Belgian told Football Italia.“It’s true we played well, but we should’ve done more. We had so many chances, Roma were very defensive and did it well, but I don’t know how many shots we had on target today.Cristiano Ronaldo, JuventusSerie A Betting: Match-day 3 Stuart Heath – September 14, 2019 Considering there is a number of perfect starts so early in the Serie A season, as well as a few surprisingly not-so perfect ones….“It’s a real shame.”Mertens came off the bench to replace Arkadiusz Milik and that didn’t help his mood.“Of course I wanted to play from the start. You know what it means for Napoli to play against Roma and I really wanted to play.”Napoli are now six points adrift leaders Juventus who may end up retaining their title.last_img read more

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Neville backs Solskjaer as Man United interim manager

first_imgManchester United legend Gary Neville believes old team-mate Ole Gunnar Solskjaer would bring back the “feel-good factor” – if named interim coachUnited parted with manager Jose Mourinho on Tuesday after embarking on their worst start to a season in 28 years following Sunday’s 3-1 defeat at Liverpool.The Red Devils added that an interim manager would be announced within 48 hours for the remainder of the 2018/19 campaign.Aside from Solskjaer, former Paris Saint-Germain coach Laurent Blanc along with another United great in Steve Bruce have been mentioned for the interim post.Although it’s believed Solskjaer will get the nod after United accidentally confirmed the news by mistake on their website on Tuesday evening before deleting the post.“I would suggest that the person who goes in for the next six months is someone who can steady the ship, knows the club, can bring people together, understands the people in the club, the fans, the media and can bring the feel-good factor back,” Neville told Sky Sports.Victor Wanyama, Tottenham Hotspur, Premier LeaguePochettino admits Wanyama remains in his Spurs plans Manuel R. Medina – September 14, 2019 Kenyan international, Victor Wanyama, was the protagonist of a summer transfer saga, but in the end, he is set to stay at Tottenham Hotspur.“Ole fits that mould, and there’s a number of other ex-players who would. At this moment in time, I can see where an interim appointment becomes someone who brings favour and goodwill, and he absolutely would. So would Laurent Blanc or Steve Bruce, as would Michael Carrick.“They would have to just steady the ship, hold the fort until the end of the season and then Manchester United can go and get what they believe to be the next manager of this football club for the next five to six months.”The former full-back reckons that whoever gets the interim manager’s job could end up becoming the new permanent boss.“If they were to win the Champions League in the next five or six months, you say ‘ok, leave them in charge!’ But, with the understanding that you’re restricting the background of the club from a technical and recruitment point of view, but you’re also making sure the head coach that actually is the best in the world comes to the club,” said Neville.“One thing the fans will not accept, those players who have flared up with the manager and you can’t silence players, but their excuse is gone now. Now they have to perform.”last_img read more

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State Seeks Project Manager for Study of Defense Manufacturing Supply Chain in

first_img Dan Cohen AUTHOR The Georgia Department of Economic Development (GDEC) plans to hire a senior project manager on a contract basis to coordinate a study on supply chain mapping.The department has been awarded a grant from the Office of Economic Adjustment to determine the impact of DOD and related federal spending on Georgia’s economy by identifying the aerospace and defense industrial base down to the 4th tier suppliers, and mapping them according to NAICS and product or service codes. The analysis portion will include construction of an economic model to ascertain how vulnerable these programs are to changes in defense spending. Once this analysis is complete, GDEC can begin to develop strategies to maximize the economic benefit of the aerospace and defense industry in Georgia. This data analysis project will enhance existing state programs in workforce and economic development by providing accurate data and identification of supply and demand for products and skilled labor.GDEC is seeking a senior project manager to assist in the coordination and completion of the supply-chain mapping. The senior project manager will work with a vendor of record, which is currently performing the survey and data collection of the suppliers in Georgia’s aerospace and defense industry. The primary role of the senior project manager will be to oversee the day-to-day operations of the grant, including overseeing deliverables, engaging and recruiting stakeholders, and leveraging relationships to achieve the goals of the grant, which are: understand the extent of the aerospace and defense contracting footprint in the state.use a project manager as focal point for efforts to strategize how Georgia can reduce the reliance of regional businesses on defense spending and develop a diversification strategy and support system for those companies that are overly reliant on defense spending.The complete request for qualifications is available on the GDEC website. For more information contact Brett Lacy, rapid response director, GDEC, at BLacy@georgia.org.last_img read more

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NOW HIRING 10 New Job Openings In Wilmington

first_imgWILMINGTON, MA — Below are some of the newest job openings in Wilmington:Full-Time Warehouse Person at PepsiFull-Time Production Technician at CutisPharmaFull-Time Expert Regulatory Affairs & Product Safety at DSM Resins & Functional MaterialsFull-Time Technician II at Charles River LabsFull-Time Associate Director at Charles River LabsFull-Time Solar Technician at SunRunPart-Time Track Operator at K1 SpeedFull-Time Sales Operations Analyst at SOVOS ComplianceFull-Time Product Management Associate at SOVOS ComplianceFull-Time Project Administrator at Trinity Building & Construction Management Corp.(NOTE: Wilmington businesses — Feel free to send me your job postings at wilmingtonapple@gmail.com.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedNOW HIRING: 60 New Job Openings In Wilmington (Week of August 11, 2019)In “Business”NOW HIRING: 10 New Job Openings In WilmingtonIn “Business”NOW HIRING: 60 New Job Openings In Wilmington (Week of July 21, 2019)In “Business”last_img read more

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Towns Current Bidding Contract Opportunities

first_imgWILMINGTON, MA — The Town’s Purchasing Department currently has the following bidding and contract opportunities available:Request For Proposals/QualificationsNoneInvitations To BidReplacement of Granular Activated Carbon (GAC) at Water Treatment Plants — Deadline: Tuesday, November 27, 2018, 11amBarrows Wellfield Replacement — Deadline: Wednesday, November 28, 11amAll interested parties must first complete the town’s Bid Registration Form.Visit the Town’s Purchasing Department website for additional information. Contact Wendy Martiniello at wmartiniello[at]wilmingtonma.gov with questions.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedTown’s Current Bidding & Contract OpportunitiesIn “Government”Town’s Current Bidding & Contract OpportunitiesIn “Government”Town’s Current Bidding & Contract OpportunitiesIn “Government”last_img read more

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Power up BP Reliance closing in on gas field near missile site

first_img[Representative image]. REUTERS/Nerijus Adomaitis/File PhotoBillionaire Mukesh Ambani’s Reliance Industries Ltd (RIL) and British partner BP Plc are reviving investment plans for a gas block close to a military missile launching facility in the Bay of Bengal, said a BloombergQuint report on Friday.Head of oil regulator Directorate General of Hydrocarbons Atanu Chakraborty told BloombergQuint that Reliance and BP are preparing a new development plan for the gas-rich NEC-OSN-97/2 block, also called NEC-25, in the Mahanadi basin offshore eastern India.”They are already in discussion with us on the technical aspects of their field development plan… reservoirs are being assessed, so that they make the final decision,” Chakraborty said in an interview to BloombergQuint in London.The new proposal follows an earlier integrated field development plan submitted in March 2013.Work on the block was hindered partly by objections from the Defence Ministry for its proximity to the Chandipur missile test base, the report said.”When you make a first move into a basin, it normally takes time,” Chakraborty clarified in the BloombergQuint report.The issues related to closeness to Chandipur missile area had to be adjusted and now the Mahanadi basin fields are maturing slowly towards development. We will see investments coming there sooner than later.– Directorate General of Hydrocarbons chief Atanu ChakrabortyA BP India spokeswoman told BloombergQuint that the company intends to progress with the field development plan within the stipulated time-frame.The report noted that Reliance and BP recently resuscitated their partnership by announcing fresh investments of $6 billion in gas projects in the Krishna-Godavari basin, which lies south of NEC-25. Indian’s biggest explorer Oil & Natural Gas Corporation also plans to spend $10 billion in deepwater projects off eastern India. Bob Dudley (right), CEO of BP gas company, and Mukesh Ambani, chairman and managing director of Reliance Industries, leave after meeting Minister of Petroleum and Natural Gas Dharmendra Pradhan in New Delhi on June 15, 2017. REUTERS/Adnan AbidiIn the year 2000, Reliance Industries and its then Canadian partner Niko Resources Ltd were awarded the NEC-25 block and made eight gas discoveries before BP picked up a 30 percent stake in the block through a $7.2-billion deal with Reliance in 2011. That transaction included similar interests in 22 other blocks. Niko exited the prospecting partnership with Reliance in 2015.The government has announced a slew of reforms, including the freedom to price and market natural gas, to push production from stalled projects as it aims to increase the fuel’s share in India’s energy mix to 15 percent by 2020 from 6.5 percent. Oil minister Dharmendra Pradhan expects investments of $20 billion by as early as 2021 to raise India’s gas output.Chakraborty said that these investments are expected to boost India’s gas production by more than two-thirds over the next five years.”We will add 50-55 million cubic meters per day of gas production on a very conservative basis,” he said. The country’s current output is about 80 million cubic meters a day.last_img read more

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Red alert in Chennai airport after caller triggers bomb scare ahead of

first_imgTwitter/Chennai (MAA) AirportA red alert was declared at the Chennai airport in the wee hours of Friday (August 9) morning after bomb threat warnings were received from the national capital.New Delhi has reportedly warned the Chennai airport of a possible bomb threat after the control room of the Delhi airport police issued an alert. The call was regarding a woman passenger on board a flight to Saudi Arabia and that she is carrying an explosive substance, The Hindu reports. After a quick meeting between the Central Industrial Security Force, Bureau of Civil Aviation Security, Airports Authority of India and other intelligence agencies, a little after midnight, the red alert was sounded and security intensified.The red alert was sounded shortly after midnight and the beefed-up security also included frisking, random checks of vehicles in parking lots as well as enhanced checking of bags. Many flights were delayed due to this.According to a report by The News Minute, the call to the New Delhi airport police control room was traced back to Salem district in Tamil Nadu but the identity of the caller is not known yet.This call comes when the security was already heightened due to the Independence day next week on August 15.Airport authorities in Chennai have asked travellers to arrive two hours early amid an increase in security.last_img read more

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1200 students sued over Shahbagh demonstration

first_imgPolice intercept a group of students demonstrating at Shahbagh crossing on Thursday. Photo: Sazid Hossain Police filed a case against 1,200 unknown students of seven government colleges in Dhaka, with Shahbagh police station for allegedly obstructing the duties of law enforcers during a demonstration at Shahbagh intersection on Thursday.    Deputy commissioner (Ramna Division) of police Maruf Hossain Sardar confirmed it on Friday noon.Students of seven government colleges affiliated with Dhaka University took position in front of National Museum near Shahbagh intersection in the capital on Thursday morning, demanding declaration of examination dates and routines.The colleges are: Dhaka College, Eden Mohila College, Begum Badrunnesa Government Women College, Government Titumir College, Kabi Nazrul Government College, Government Shaheed Suhrawardi College and Government Bangla College.At one stage, police fired tear gas shells to disperse the students.The students alleged they were beaten up, leading to the injuries of a number of students.Police detained 13 students from the spot.last_img read more

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Astronomers take a closer look at emission from the supernova remnant MSH

first_imgSuzaku XIS1 image of the SW rim of MSH 15−56 in the 0.3−10 keV energy band. The SW region is shown by the blue elliptical area. The background region is indicated by the dashed box, and the white box represents the FoV of XIS1. Credit: Cesur et al., 2019. Citation: Astronomers take a closer look at emission from the supernova remnant MSH 15−56 (2019, June 5) retrieved 18 August 2019 from https://phys.org/news/2019-06-astronomers-closer-emission-supernova-remnant.html More information: Nergis Cesur et al. A study of the composite supernova remnant MSH 15-56 with Suzaku, 2019. arXiv:1905.12473v1 [astro-ph.HE]. arxiv.org/abs/1905.12473 By analyzing archival data from the Suzaku X-ray satellite, astronomers have learned important information regarding thermal and non-thermal emission from the composite supernova remnant (SNR) designated MSH 15-56. Results of the study, available in a paper published May 29 on arXiv.org, could be helpful in advancing the knowledge about composite SNRs residing in the Milky Way galaxy. Astronomers investigate pulsar wind nebula DA 495 © 2019 Science X Network Supernova remnants (SNRs) are diffuse, expanding structures resulting from a supernova explosion. They contain ejected material expanding from the explosion and other interstellar material that has been swept up by the passage of the shock wave from the exploded star.When SNRs consist of an expanding shell into a surrounding medium and a pulsar wind nebula (PWN), they are called composite supernova remnants. This subclass represents a unique evolutionary phase of SNRs, where X-ray, gamma-ray and radio observations allow astronomers to study of the co-evolution of the emission from the shell-like shock front and from the PWN.Located some 13,400 light years away, MSH 15-56 (other designations: G326.3−1.8 and Kes 25) is a composite SNR containing a remnant shell and a displaced PWN with a comet-like morphology. Previous observations have revealed that the PWN resides in the southwest rim of MSH 15-56 and has a radius about 3.6 times smaller than that of the whole SNR.Given that X-ray observations have the potential to reveal detailed information about composite SNRs, a team of astronomers led by Nergis Cesur of Radboud University in Nijmegen, the Netherlands, decided to conduct a study of MSH 15-56 using data provided by the Suzaku X-ray astronomy spacecraft. An analysis of the data allowed them to investigate the nature of the emission and spectral parameters of this remnant.”Although the X-ray properties of the thermal and non-thermal emission were studied in detail by Yatsu et al. (2013) and Temim et al. (2013), we study this SNR using more recent atomic database (AtomDB) version 3.0.9 and give a comparison of metal abundances with xspec and spex software packages, which provide almost consistent results with each other except a few parameters,” the astronomers wrote in the paper.According to the paper, thermal and non-thermal emission from the southwest rim of MSH 15-56 were also found during the analysis of Suzaku data. The results are indicative of the interactive relation between the PWN and the thermal emission. pointing out the material in the remnant interior and an interaction of the SNR reverse shock with the pulsar wind nebula.”It is therefore likely that the thermal component integrated with the PWN spectrum may be explained by the morphological relation between the PWN and the shell region,” the paper reads.The astronomers added that the thermal component, with an electron temperature of around 0.64 keV and ionization timescale of approximately 100 billion cm3/s, dominates nearly half of the X-ray spectrum, accounting for about 54 percent of the total unabsorbed flux.Moreover, the researchers found slightly enhanced abundances of neon (Ne), magnesium (Mg), sulfur (S) and an enhanced abundance of silicon (Si) in the spectrum of MSH 15-56. These findings, according to the study, support evidence of ejecta heated by the reverse shock.”This result together with the small X-ray-emitting mass suggests that its emission arises from the shock heated ejecta,” the authors of the paper concluded. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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David Bakhtiari T Knee DNP Limited Limited Questio

first_imgDavid BakhtiariTKneeDNPLimitedLimitedQuestionableTrevor DavisWRHamstringDNPDNPDNPOutKevin KingCBHamstringLimitedLimitedLimitedQuestionableEquanimious St. BrownWRElbowLimitedLimitedLimited— Bashaud BreelandCBGroinDNPLimitedLimitedQuestionable Leonard JohnsonCBHipFullFullFull— Top Stories The Arizona Cardinals will travel to one of the oldest and most historic stadiums on the NFL circuit this week as they take on the Green Bay Packers. With temperatures forecast in the mid-30s and healthy bodies at a premium over the last two weeks, the Cardinals could face some unique challenges at Lambeau Field.Both teams are riding losing streaks, but the Packers have not lost a game at home this season with a 4-0-1 record in Wisconsin. Derrick Hall satisfied with D-backs’ buying and selling Grace expects Greinke trade to have emotional impact Mike DanielsDEFootDNPDNPDNPOut Rudy FordSHeelLimitedFullFullQuestionable Larry FitzgeraldWRNot Injury RelatedDNPFullFull— Daily Practice Designations:DNP-Did Not ParticipateLimited-Limited Participation (Less than 100% of normal repetitions)Full-Full Participation (100% of normal repetitions)(-) (Not listed) Jimmy GrahamTEKnee/ThumbDNPLimitedLimited— 0 Comments   Share   Robert NkemdicheDTCalfFullFullFull— Aaron RodgersQBKneeFullFullFull— Will the Cardinals have Budda Baker back? Will D.J. Humphries play? How about Deone Bucannon, Rudy Ford and Chad Williams, who all missed Week 12 against the Los Angeles Chargers?Related LinksThe Consensus Week 12: Cardinals almost unanimously lastDoug & Wolf Week 12 NFL power poll: John Clayton makes his picksBelow is the official Week 13 NFL injury report for the Cardinals and the Packers, who play at 1 p.m. on 98.7 FM Arizona’s Sports Station. PlayerPositionInjuryWednesdayThursdayFridayGame Status Kentrell BriceSAnkle/ConcussionDNPDNPDNPOutcenter_img Tra CarsonRBRibDNPDNPDNPOut Randall CobbWRHamstringLimitedLimitedLimitedQuestionable Game Status Designations:Out-Will not playDoubtful-Unlikely to playQuestionable-Uncertain if player will play Haason ReddickLBNeckDNPLimitedLimitedQuestionable Chad WilliamsWRAnkleLimitedLimitedLimitedQuestionable Deone BucannonLBChestDNPDNPDNPOut Budda BakerSKneeLimitedLimitedFullQuestionable PlayerPositionInjuryWednesdayThursdayFridayGame Status John PhillipsTEKneeFullFullFull— Former Cardinals kicker Phil Dawson retires Lane TaylorGQuadricepLimitedLimitedLimitedQuestionable The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Raven GreeneSAnkleDNPDNPDNPOut Mike IupatiOLBackFullFullFull— D.J. HumphriesOTKneeLimitedLimitedLimitedQuestionable Corey PetersDTBackLimitedLimitedFull—last_img read more

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AE Networks is expanding the Polish footprint of

first_imgA+E Networks is expanding the Polish footprint of factual entertainment channels after striking a deal with Orange TV.History, Lifetime, Crime+Investigation and H2 are all now available on Orange TV’s newly-launched IPTV service in Poland.History is available on Orange’s Optimal, Rich and Max packages, while Lifetime, Crime+Investigation and H2 sit within Rich and Max tiers.“A+E Networks’ channels are successful, appreciated and well-recognized by Polish viewers. We are very pleased that Orange is adding all four channel brands available in the territory to its newly-created offering, enabling Orange TV’s subscribers to enjoy our exciting programming line-up this spring,” said Izabella Wiley, general manager, A+E Networks Poland.last_img read more

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European public broadcasters organisation the EBU

first_imgEuropean public broadcasters’ organisation the EBU has expressed concern about political pressure being exerted on Lithuanian pubcaster LRT.The EBU highlighted the creation of an ad hoc investative commission by the Lithuanian parliament to look into the management, finances and economic activities of the broadcaster, which the EBU said was placing “an excessive burden” on LRT.EBU Director General Noel Curran has written to the speaker of the Lithuanian Parliament Viktoras Pranckaitis, the prime minister Saulius Skvernelis and Lithuanian president Dalia Grybauskaitė to express his concerns.The EBU argues that any investigation into LRT’s activities should be carried out by an independent professional body such as its supervisory council or by the national state audit body.The EBU’s letter urges the Lithuanian authorities to refrain from any action which would impede LRT’s ongoing operations and to safeguard the institutional and editorial independence of the broadcaster.The EBU has expressed concern in recent years about growing politicisation of issues related to public broadcasting and changes to media regulations, as well as funding issues, in a number of countries in central and eastern Europe.last_img read more

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The explosive growth of Internet video traffic has

first_imgThe explosive growth of Internet video traffic has put pressure on video transcoding infrastructures to optimize bandwidth, power consumption and cost of operations. High density transcoding solutions such as Intel’s Quick Sync Video technology have emerged to address these challenges. They introduce various levels of HW acceleration to off-load computationally intensive tasks. Initially targeted at consumer applications, high density transcoding has become a viable option for professional transcoding infrastructures when included in suitable packages that address the requirements of professional applications.last_img read more

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ShareTweet

first_imgShareTweet Gardai say the woman was driving an English-registered car while the man was driving an Irish-registered car.There were no passengers in the vehicles.The road in Fahan remains closed while the crash scene is investigated by Gardai determine how it happened.DERRY WOMAN KILLED IN TWO-VEHICLE CRASH IN CO DONEGAL was last modified: December 23rd, 2016 by John2John2 Tags: DERRY WOMAN KILLED IN TWO-VEHICLE CRASH IN CO DONEGALfahangardailetterkenny hospital£7center_img A WOMAN believed to be from Derry has died following a crash in Co Donegal.The 25-year-old woman was involved in a two-vehicle collision in Glebe just before 11 pm last night, Thursday, December 22.The second driver, a man in his 20s, has been taken to Letterkenny Genral Hospital, but his injuries are not believed to be life threatening.last_img read more

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By Darren Kaiser International Man It is said t

first_imgBy Darren Kaiser, International Man It is said that hindsight is 20/20. It’s easy to think, “If I had just bought apartments in Paris in the 80s, or tech stocks before the bubble, or gold in 2000 or 2001, I’d be sitting on a fortune right now.” The thing is, kicking yourself for lost opportunities doesn’t do you much good. A better strategy is to start focusing on not missing “home run” type investments like these in the future. So, how does one go about cashing in on fast-moving trends and identifying “the next big thing”? Many will tell you that making money like this is all about chance, that you just have to be lucky. Well, I’d be lying if I said there wasn’t some luck involved, but the quote “the harder I work, the luckier I get” by Samuel Goldwyn comes to mind. Making a perfectly-timed entry and exit into any market will take some luck, but careful calculation and consideration will allow you to successfully identify the trend in the first place. So, here is the formula for spotting and cashing in on trends: Modeling. If possible, base your research on a real-life example (or two) elsewhere in the world. If you’re evaluating a real estate opportunity, find places that were similar to your given market 5, 10, or 20 years ago, and study how they evolved over time. If you’re looking at the spending habits of a country that has a rapidly growing middle class, look at another country with similar cultural characteristics that went through the same change in the past, and find sectors which became much more popular during their years of growth. For example, I’ve been studying both urban and rural real estate trends for several years. When looking at urban areas, I’ve noticed there is a very common progression that usually takes place within city centers. The industrial/rundown areas close to downtown become popular with artist/bohemian types, because rents are low, there are plenty of vacant places, and getting around is easy. With their art galleries, concerts, coffee shops, and loft apartments, these areas become much more attractive over time. Within five or ten years, it’s common for the neighborhood to go through a complete transformation. Spotting these trends early can lead to big wins.   Ear to the ground. The more you can learn about the current situation you’re analyzing, the more success you’ll have. Keep up with breaking news related to the industry. Spend time in the field and get to know the people who work in the industry, but not just the most established players. Identify the future “movers and shakers”, and try to understand what the next generation is going to want.   Economic support. It’s very important after you’ve spotted a trend to evaluate whether the local financial/economic situation will support the trend over the coming years. If incomes in a certain area are rising, many sectors will do well. However, even in slower economies, you can still boost your profits by hand picking your market. If interest rates are rising, you’ll have to be careful, because it means people are going to be paying more for credit (most likely, limiting their spending). If you can find a place with expanding credit and strong consumer spending, there is a good chance your trend could have a long way to run.   Gumption. After you’ve done your research and identified a promising trend, make your plan and stick to it. Often, when you find a trend that really presents a lot of opportunity, no one else is investing in it at the time. This means your family, friends, and neighbors will most likely call you “crazy” for considering putting your time and energy into such a “hair brained” idea. Contrarian investors know all about this. Long ago, I considered investing in organic agriculture stocks (back when they sold for pennies) but was talked out of it by friends and family. When I started investing in gold at less than $750 per ounce, most people I knew told me I was going to lose all my money. They said the same thing when I started buying property in Chile. Moral of the story: don’t lose your nerve at the last minute. One of the best things about living an international lifestyle is gaining some experience and insight which can allow you to spot trends in places where the local population would have a hard time identifying them. With all the emerging economies in Latin America and Asia right now, new trends are developing all the time. You can decide if you want to invest passively (stocks or hard assets), or more aggressively (through operating a business), and there are opportunities to suit anyone’s fancy. There’s a whole wide world out there to explore, and spotting a new trend now could make all the difference further down the road. [Spotting good opportunities ahead of the curve is a key focus of World Money Analyst. Take your risk-free test drive here and discover for yourself what the average person thinks is “crazy”.]last_img read more

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A note from the editor Please consider making a v

first_imgA note from the editor:Please consider making a voluntary financial contribution to support the work of DNS and allow it to continue producing independent, carefully-researched news stories that focus on the lives and rights of disabled people and their user-led organisations. Please do not contribute if you cannot afford to do so, and please note that DNS is not a charity. It is run and owned by disabled journalist John Pring and has been from its launch in April 2009. Thank you for anything you can do to support the work of DNS… Two senior political figures have called for an inquiry into claims that police have targeted and assaulted disabled people taking part in peaceful anti-fracking protests.Both the co-leader of the Green party, Jonathan Bartley, and Labour’s shadow chancellor, John McDonnell, have called for an inquiry into the actions of Lancashire police.Bartley said he was “incredibly concerned” about what he had been told, and that it was clear disabled people had been “abused” and were being subject to discriminatory treatment by Lancashire police.He has called for an independent inquiry, after Disability News Service (DNS) reported concerns last week about police actions at protests across the country and particularly one focused on the drilling activities of the energy company Cuadrilla at Preston New Road, on the edge of Blackpool.As well as disabled people, protesters believe that older people, women and younger people have also been targeted by police.McDonnell, although not available to speak to DNS this week, has spoken of the need for an inquiry into the “unacceptable” level of “physical force” that appears to have been used by Lancashire police.The shadow chancellor, who has visited Preston New Road, says in a film about the targeting of anti-fracking protesters, produced for the Netpol police monitoring network by Gathering Place Films, that he was shocked by what he had heard from protesters and had seen in video footage and was “really worried about the physical nature” of the policing.He says in the film (pictured): “I think there is a need for an inquiry of some sort into what’s happening with the policing operation overall.“The evidence that I’ve seen is deeply worrying and I think if other people see it as well, they will feel the same way as me.”Bartley has also visited Preston New Road and has spoken to disabled people and other protesters.He told DNS this week that he could not prove that disabled people were being deliberately targeted by police officers, but that there was “an awful lot of circumstantial evidence that it is happening”.He added: “What is clear is that disabled people are being abused by the police. I think that’s clear. It’s abuse.”And he said there needed to be an independent inquiry into what had been happening.The Independent Office for Police Conduct (IOPC) said this week that it had no current investigations into the actions of Lancashire police at Preston New Road, but that it was continuing to “monitor the situation”.But Bartley accused the IOPC of being “mealy-mouthed” and said its statement was “a cop-out” and that action needed to be taken before someone was seriously injured.He also said Lancashire police needed to make it clear the steps it would take to ensure the safety and rights of disabled protesters were protected. And he said there was “ample evidence” to show that the force was not currently doing that.Despite the call for an inquiry by McDonnell, Lancashire’s police and crime commissioner, Labour’s Clive Grunshaw, has backed the force’s tactics and has told DNS that he is “reassured that the tactics available to officers and used on the ground are all in line with Home Office and College of Policing guidelines”.He said he did not support the call for an independent inquiry into the policing tactics.He said: “Officers react to situations they are faced with and respond in a legitimate and proportional manner.“The prime consideration of the police presence, and the approaches they take, is to keep everyone safe at the site.”DNS spoke last week to three disabled protesters, and two other eye-witnesses, who all experienced or witnessed serious and repeated incidents of police brutality targeted at disabled people taking part in the Preston New Road protest.Disabled protesters have described being kicked, punched, knocked unconscious, and tipped out of their wheelchairs.One of the disabled protesters Bartley has spoken to, at another fracking site in Lancashire, is veteran Green party member Anne Power.Video footage shot by protesters, and reported by the Independent last year, showed Power, who is in her 80s, being dragged across a road by police officers while protesting peacefully outside the site near Little Plumpton.Bartley said: “I know Anne, I know her character, I know her integrity, her honesty.“To see the way that she has been treated and to see the video of the way she has been treated and to hear it first hand from her is frankly shocking.”Bartley, who himself was pushed to the ground and then dragged along a road by police officers while trying to deliver a speech at an anti-fracking protest at Kirby Misperton in Yorkshire in November 2017, warned that the events in Lancashire and at other anti-fracking protests needed to be put in the context of other attacks on the rights of protesters.He pointed to the anti-terror laws used against the Stansted 15, and the 15- and 16-month prison sentences imposed on the Frack Free Three (protesters at Preston New Road, whose sentences were later quashed on appealed).Bartley said a pattern was developing of the views of local communities “being ridden roughshod over” and then their democratic right to protest being taken away.He said: “There seems to be a concerted effort across the board to clamp down on protest.“We are seeing every mechanism at the establishment’s disposal being used.”And he said he would not be surprised – once parliament had settled the Brexit logjam – if the government brought forward “even stronger laws that take away people’s civil liberties further”.There are fears that forces across the country that have policed anti-fracking protests are developing a tactics “template” that can be used to target disabled people taking part in other peaceful protests, such as those organised by the anti-cuts and climate change movements.Last week, Andy Greene, a member of the national steering group of Disabled People Against Cuts, warned that there had been an “escalation” and a “clear direction of travel” in police tactics since the anti-fracking protests at Balcombe, in Sussex, in the summer of 2013.He said police tactics were becoming “more physical… more confrontational, more provoking” and that he expected these police tactics to be “rolled out across the protest movement” over the next year as the country sees a likely increase in political volatility around issues such as anti-fracking, anti-austerity and Brexit.Grunshaw said in a statement: “The policing operation on Preston New Road is in place to ensure public safety on what is a very busy and vital route and I am reassured that the tactics available to officers and used on the ground are all in line with Home Office and College of Policing guidelines.“Officers at the fracking site are caught between competing demands of facilitating peaceful protest and allowing companies to conduct their lawful business, as well as keeping an important emergency services route open.“Where people do have concerns about the actions of the police, there is a robust complaints procedure in place, overseen by myself.“Anyone who is unhappy with the outcome of the complaints process has the right to appeal to the independent body the IOPC.”He said Lancashire police had upheld just five complaints about its Preston New Road policing operation, out of 217 complaints, between January 2017 and last month, while there had been 434 arrests and 429 charges.Meanwhile, the IOPC has confirmed that it failed to uphold an appeal by wheelchair-user Nick Sheldrick after Lancashire police had rejected his complaint, following an incident in February, and found that his complaint “had been properly addressed and all appropriate lines of enquiry had been followed”.Last week, Sheldrick told DNS that he had been tipped out of his wheelchair six times by police at Preston New Road and believes that only one of these incidents was accidental.But the IOPC did uphold a single complaint earlier this year by another protester that the force should have recorded their complaint.An IOPC spokeswoman said: “We take incidents where it is alleged someone has suffered a serious injury as a result of use of force, or has been discriminated against, very seriously.“We do not have any independent investigations relating to the incidents reported.“We are aware of the anti-fracking demonstrations, as reported in the media, and we have recently been in contact with Lancashire Constabulary.“The force has assured us that any complaints received have been dealt with appropriately, and did not meet the criteria to be referred to us.“We will continue to monitor the situation, and will be in regular contact with the force about this going forward.”Lancashire police said last week that its intention was to “ensure a consistent and coordinated policing response and ensure a balance between the rights of people to lawfully protest, together with the rights of the wider public, including local businesses, to go about their lawful activities.“We aim to prevent, where possible, crime and disorder, but if it does occur we will provide an effective, lawful and proportionate response.”Picture by Gathering Place Filmslast_img read more

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11 Cannabis Predictions for 2019

first_img Editor in Chief of Green Entrepreneur Next Article Industry experts look into their crystal bongs and tell us what to expect in the ever-growing cannabiz. 5 min read Resolutions Download Our Free Android App Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine. Image credit: Yarygin | Getty Images It looks like 2019 may be a blazing year for cannabis. We asked a bunch of successful entrepreneurs what to expect. 1. Cannabis will become more mainstream.”Thought leaders, CEOs, government officials and local community leaders will continue to drive the new and emerging narrative in mainstream media: Cannabis is here to stay and the people buying the products are our neighbors, physicians, stay-at-home parents, young adults, seniors and more,” says Nick Kovacevich, CEO of KushCo Holdings.2. Latin America will make a big play.”Colombia and Mexico are poised to establish their global dominance in short order, which leads to my prediction that cannabis will soon become a very valuable, sizeable addition to Colombia’s legal agricultural exports and local economy,” says Jessica Billingsley, co-founder and CEO of MJFreeway.3. Big Pharma will join the CBD party. “While beverage and alcohol companies are joining the CBD bandwagon, it makes sense that big pharma will step in, too,” says Dr. Jonathan Rothbard, senior research scientist at Katexco Pharmaceuticals  “Many pharmaceutical companies have identified small molecular weight and orally bioavailable agonists of cannabis. Of course, there will be a plethora of start-ups, but relatively few serious companies designing cannabis-derived drugs will make it far for the obvious reason that unlike “natural products”, new pharmaceuticals will take an average of 10 years to develop.”4.  New Jersey will be next state to legalize recreational marijuana. “New Jersey is most likely going to legalize adult-use cannabis, becoming the second state after Vermont to do so through legislative means, and the first state through legislative means to create a retail market for it,” predicts Joe Lusardi, President & CEO of Curaleaf. Indeed the New Jersey legislature is closer to passing marijuana legalization bill, S-2703, which would make it legal to possess up to 1 ounce of marijuana and consume it at home or in specifically designated areas. Related: New Jersey Takes a Big, and Long Awaited, Step Toward Full Legalization5. More demand for transparency.”Millions of Americans and Canadians will try cannabis for the first time or returning after a decades-long hiatus. In both cases, they don’t know what to expect, and frankly, the well-intended information provided on websites and in dispensaries doesn’t go far enough,” says  PAX CEO Bharat Vasan. “The next big hurdle for the industry is to provide our consumers with quality, transparency and predictability in their sessions. Technology can help.”6. Expect lots more consolidation.”As the industry matures, larger businesses are buying up smaller ones in order to increase operational efficiency and profitability,” says Neil Yorio, EVP Agricultural Lighting at BIOS Lighting. “The evolution of the grower from the clandestine operations during prohibition to a legalized market today garners the influx of science and technology experienced growers from more traditional horticultural or farming backgrounds.”7. Look for CBD to pop up in mainstream stores.”We will begin to see CBD-infused drinks become the norm at big box stores, and a rush of CBD infused topicals make their way onto the shelves of our familiar pharmacies and big brand name beauty counters, ” says Cynthia Salarizadeh, Managing Partner of KCSA Strategic Communications.Related: Hemp Hemp Hooray! U.S. Legalizes Hemp8. Vapes, terpines and edibles on the rise.According to Kevin Ahaesy, CEO of EcoCannabis, “Vape pens and edible products will continue to rise in popularity, as flower sales decline. Terpenes will become increasingly important to those seeking specific effects from the plant.  We will also see a sharp increase in senior consumers, with CBD products being the main driver for this increase.”9. California will get its act together.”This is going to be the year of the legacy California cannabis brands/companies, as many have weathered the storm and tumult of adapting to regulations in 2018 and now with a more clear path forward will be able to refocus on continued growth and expansion into new markets,” says Bryce Berryessa, President of La Vida Verde.10. More much-needed research.”As a result of a more open regulatory environment, we will also see increased research, which will drive innovation. The passage of the Farm Bill, which will open up the CBD market in 2019, will help accelerate research that will support cannabis overall. As we start to uncover the power of each specific cannabinoid, we will see more targeted treatment through very specific combinations of these cannabinoids,”  says Nancy Whiteman, Founder and CEO of Wana Brands.11. Banks will finally get on board.“I predict in 2019 that we will see some sort of banking reform at the federal level for cannabis companies allowing licensed companies to acquire a bank account,” says Taylor Blake, co-producer of The Emerald Cup.Related: 10 Cannabis Executives Predict How AG Jeff Sessions’ Retirement Will Affect the Marijuana Industry center_img 11 Cannabis Predictions for 2019 –shares January 1, 2019 Free Green Entrepreneur App Entrepreneur Staff Jonathan Small Add to Queuelast_img read more

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Novel DNA nanoplatform delivers anticancer agents to multidrugresistant tumors

first_img Source:https://onlinelibrary.wiley.com/page/journal/15213773/homepage/press/201835press.html Reviewed by James Ives, M.Psych. (Editor)Nov 22 2018A tailored DNA nanoplatform carries chemotherapeutic drugs and RNA interference toward multidrug-resistant tumorsOne of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance. Chinese scientists have now developed a nanoplatform that selectively delivers small hairpin RNA transcription templates and chemotherapeutics into multidrug-resistant tumors. A deadly cocktail of gene-silencing elements and chemotherapeutic drugs effectively and selectively kills cells, they reported in the journal Angewandte Chemie. The nanoplatform was assembled using established DNA origami techniques.Multidrug-resistant cancer cells often remove potent drugs from the cell before they can become effective. As several genes for proteins that perform this job are known, scientists attempt to interfere on the gene expression level, which is possible with RNA interference (RNAi) techniques: small RNAi strands combine with messenger RNA and inhibit transcription. However, RNA transcription templates must be delivered and released into the cytoplasm of the cell, and at the same time, a potent drug must be present to kill the cell.Baoquan Ding at the National Center for Nanoscience and Technology, Beijing, China, and his colleagues have now designed and built a platform that includes every item needed to intrude into tumor cells and release gene-silencing elements and chemotherapeutic drugs. They built the platform using the DNA origami technique, which allows the construction of nanosized DNA objects in multiple, and even very complicated shapes. In this case, the scientists constructed a relatively simple DNA origami structure, which self-assembled into a triangular nanoplatform with various sites to bind multiple functional units.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsHIV DNA persists in spinal fluid despite treatment, linked to cognitive impairmentStudy reveals time taken for DNA repair after chemotherapyOne of the key features of the platform was that it could include the hydrophobic potent drug doxorubicin (DOX), a cytostatic that is especially useful against malign tumors. Here, DOX did not bind to the nanoplatform by any covalent linkage, but was loaded onto it through intercalation (which is the way DOX works in the cell: it intercalates into DNA, inhibiting transcription). Instead, what was covalently linked to the platform was the multiple gene silencing and cell-targeting site, which consisted of two linear small hairpin RNA transcription templates for RNAi and gene therapy, a cell-specific unit for specific recognition and insertion by the tumor cell, and a disulfide linkage to be cleaved by cellular glutathione.The authors examined their multipurpose nanoplatform with an in vitro assay (on cell cultures) and by administering it into mice containing multidrug-resistant tumors. They found both a high and selective delivery and release rate of DOX and RNA transcription templates, and a high and selective tumor-killing efficiency. In addition, the multifunctional platform itself was not harmful to mice; however, filled with drugs and delivery sites, it was effective and deadly to multidrug-resistant tumors, the authors reported.This research demonstrates what is possible in cancer therapy. The scientists have designed a nanostructure that not only specifically targets cancer cells, thus reducing severe side effects in chemotherapy, but also carries a drug and everything needed to suppress resistance in the cell when releasing the drug. And the platform itself is modifiable; adaption to other delivery strategies and other therapeutic components is easily possible, according to the authors.last_img read more

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